Tolerance: Clonazepam is a long half-life benzodiazepine. Duration of action after a single dose is determined by redistribution rather than metabolism. Tolerance develops to the anticonvulsant effects. It does not develop to the anxiolytic effects (Vinkers ). Chronic use of this agent may increase the perioperative. (Benzodiazepine) (Dose Comparison) (Peak) (Half-life) Alprazolam hrs. hrs. (Xanax) Bromazepam hrs. hrs. (lexotan) Chlordiazepoxide hrs. hrs. (librium) Clobazepam hrs. hrs. (Frisium) Clonazepam hrs. hrs. (klonopin) Clorazepate (benzos) Klonopin duration of effects vs half life. Benzodiazepines. Half-life (hrs) [active metabolite]. Approximately Equivalent Oral dosages (mg). Market Aim. Alprazolam (Xanax, Xanor, Tafil). a. Bromazepam (Lexotan, Lexomil). a. Chlordiazepoxide (Librium). . a. Clobazam (Frisium). a,e. Clonazepam (Klonopin, Rivotril).
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