Carvedilol dosing depends on the conditions of the patient after considering the number of factors including your age, medical condition, and other medications that you are taking. It is also important to know if you are hypersensitive to this medicine or any other similar medications. Thus the dosing list varies from patient to patient. It is always recommended to follow your doctor’s advice as the dosage may be increased or decreased due to certain reasons. Also he may prescribe diuretic or some other medicine if your blood pressure is not controlled by carvedilol alone.
The usual initial dosing for high blood pressure or hypertension is 6.25 mg, taken twice daily for couple of weeks. The dosage may be increased anywhere from 7 to 14 days to a maximum dosage of 20 to 25 mg twice a day. If tolerated, using standing systolic pressure about 1 hour after dosing, maintain dosage for 7 to 14 days. Then increase the dosage to 40 mg once daily if needed based on trough systolic standing blood pressure. Maintain this dosage for 7 to 14 days and adjust to Maximum 80 mg once daily if tolerated and needed. Total daily dose should not exceed 80 mg.
The usual initial carvedilol dosing for patients with Heart failure caused by ischemia or cardiomyopathy is 3.125 mg taken twice for 2 weeks. The dosage may be increased to 6.25 mg twice daily if tolerated. If you are weighing less than 85 kg or 187 lb, the dosage should not exceed 25 mg. On the contrary, if you are weighing more than 85 kg or 187 lb, the dosage should not exceed 50 mg. Or 10 mg in taken daily for 2 weeks and if tolerated it may be increased to 20 mg, 40 mg, and 80 mg over successive intervals of at least 2 weeks.
The usual initial dosing for patients with Left ventricular dysfunction following myocardial infarction is 6.25 mg taken twice daily. Based on tolerability the dosage may be increased to 12.5 mg after 3 to 10 days. Then increase to a target dose of 25 mg taken twice. Also a lower starting dose is 3.125 mg twice a day, or slower slower titration may be used if clinically indicated. Or other option is of 20 mg once daily, increase after 3 to 10 days to 40 mg daily if tolerated, then increase to target dose of 80 mg daily. A lower starting dose of 10 mg daily may be used or the rate of up titration may be slowed if clinically indicated.
It should be used cautiously in patients with renal or hepatic impairment, pulmonary disease, diabetes mellitus, hypoglycemia, thyrotoxicosis, peripheral vascular disease, hypotension, respiratory depression, elderly patients, pregnant or breastfeeding patients and children.
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